PPP2R5D (H5D12) Mouse mAb
货号：
5687S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5687S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Protein Phosphatase 2A subunit isoform R5-δ (PPP2R5D) belongs to the R5/B/B56 family of the regulatory subunit B of serine/threonine phosphatase 2A (1). PPP2R5D (B-δ) is structurally related to the other components of subunit B, B-α. PPP2R5D lacks the WD-40 repeats that are important for protein-protein interaction (1-2). Structural differences may contribute to distinct down stream effects (3) and directing PP2A nuclear localization (4). Current evidence suggests that in contrast to B-α, PPP2R5D modulates the TGF-β/Actividin/Nodal signaling pathways by restricting the downstream activities of the type I TGF-β receptors, ALK4, and ALK5 (3)蛋白磷酸酶2A亚基异构体R5-δ (PPP2R5D)属于丝氨酸/苏氨酸磷酸酶2A的调节亚基B的R5/B/B56家族(1)。PPP2R5D (B-δ)和亚基B(B-α)的其它成分结构上相关。PPP2R5D缺少对于蛋白-蛋白相互作用很重要的WD-40重复序列(1-2)。结构差异可能有助于区分下游的效应(3)并指引PP2A的核定位(4)。现有的证据表明和B-α相比，PPP2R5D通过限制1型TGF-β受体、ALK4和ALK5的下游活性来调节TGF-β/Actividin/Nodal信号通路(3)。 |
| 存放说明 | -20C |
| 计算分子量 | 66, 69 |
参考图片Western blot analysis of extracts from MCF7, HeLa, and Hep G2 cells using PPP2R5D (H5D12) Mouse mAb.Western blot 检测MCF7, HeLa和Hep G2 细胞提取物，使用的抗体为PPP2R5D (H5D12) Mouse mAb。 |
