| 货号 | 38410S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | SNF2H (D4W6N) Rabbit mAb recognizes endogenous levels of total SNF2H protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Sucrose nonfermenting 2 homolog (SNF2H, SMARCA5) is one of two orthologs of the ISWI (imitation switch) ATPases encoded by the mammalian genome (1). SNF2H is part of the SNF2 family of chromatin remodeling factors that use ATP hydrolysis to catalyze biochemical reactions in several mammalian chromatin-remodeling complexes, including ACF1, RSF1, CHRAC, NoRC, WSTF, and WCRF180 (2). Research studies show that SNF2H is crucial for chromatin organization, DNA damage response, and differentiation (1-7). The SNF2H helicase facilitates DNA damage repair by actively moving nucleosomes for DNA damage response (DDR) proteins to effectively associate with damaged regions (3). Additional studies show that repair of double stranded breaks (DSBs) significantly decreases in the absence of SNF2H (3), and these cells become highly sensitive to DNA damage caused by x-rays and chemical treatments inducing DSBs (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 125 |
| 参考文献 | 1 . Lazzaro, M.A. and Picketts, D.J. (2001) J Neurochem 77, 1145-56. 2 . Kasten, M.M. et al. (2011) Cell 144, 310.e1. 3 . Helfricht, A. et al. (2013) Cell Cycle 12, 3070-82. 4 . Mueller, A.C. et al. (2013) Oncogene 32, 1164-72. 5 . Lan, L. et al. (2010) Mol Cell 40, 976-87. 6 . Smeenk, G. et al. (2013) J Cell Sci 126, 889-903. 7 . Chioda, M. et al. (2010) Development 137, 3513-22. |
Western blot analysis of extracts from K-562, HCT 116, and HeLa cell lines using SNF2H (D4W6N) Rabbit mAb. |
