| 货号 | 41377S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | MTHFD2 (D8W9U) Rabbit mAb recognizes endogenous levels of total MTHFD2 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase involved in mitochondrial folate metabolism (1). MTHFD2 expression is developmentally regulated, as it is expressed in embryos but not in most adult tissues. Recent research studies have shown that MTHFD2 is consistently overexpressed in many cancer types and correlated with poor survival in breast cancer (2-5). Overexpression of MTHFD2 promotes cell proliferation while its depletion induces cell death in human cancer cells (6). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
| 参考文献 | 1 . Christensen, K.E. and Mackenzie, R.E. (2008) Vitam Horm 79, 393-410. 2 . Lehtinen, L. et al. (2013) Oncotarget 4, 48-63. 3 . Nilsson, R. et al. (2014) Nat Commun 5, 3128. 4 . Liu, F. et al. (2014) Tumour Biol 35, 8685-90. 5 . Tedeschi, P.M. et al. (2015) Mol Cancer Res 13, 1361-6. 6 . Gustafsson Sheppard, N. et al. (2015) Sci Rep 5, 15029. |
Western blot analysis of extracts from HeLa and 293 cells using MTHFD2 (D8W9U) Rabbit mAb. |
