PTP-PEST (AG10) Mouse mAb
货号：
4864S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4864S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | PTP-PEST (AG10) Mouse mAb detects endogenous levels of total PTP-PEST protein. This antibody does not cross-react with other protein tyrosine pho sphatases. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | PTP-PEST is a ubiquitously expressed cytosolic protein tyrosine phosphatase with multiple proline-rich regions that appear to be the the docking sites for PTP-PEST binding partners or substrates (1). PTP-PEST regulates fibroblast adhesion, migration and cytokinesis through its association with and dephosphorylation of p130 Cas, paxillin, PSTPIP1, WASp, and other adhesion molecules (1-5). By modulating phosphorylation states of Shc, Pyk2, Fak and WASp, PTP-PEST negatively regulates of lymphocyte activation (1,6). In mammary epithelial cells, EGF facilitates the dephosphorylation of Jak2 by PTP-PEST, thereby interfering with lactogenic hormone PRL signaling (7). PTP-PEST dephosphorylates c-Abl as well, which affects the phosphorylation states of PTP-PEST substates such as paxillin, p130 Cas, Crk and PSTPIP1 (8). |
| 存放说明 | -20C |
| 计算分子量 | 110 to 125 |
参考图片Western blot analysis of extracts from THP1, HeLa and U-937 cells using PEP-PEST (AG10) Mouse mAb.使用PEP-PEST (AG10)鼠单抗对THP1，HeLa和U-937细胞提取物进行western blot分析。 |
