PVR/CD155 (D3G7H) Rabbit mAb
货号：
13544S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13544S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | <p>Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6).</p>脊髓灰质炎病毒受体（PVR, CD155）是一个免疫球蛋白样样，跨膜糖蛋白，最初被描述为脊髓灰质炎病毒与细胞附着的媒介，后来才发现它在粘着连接形成时有重要作用。PVR也被称为nectin-like5（Necl-5），可以和nectin-3结合，与integrin αvβ3和 PDGFR相互作用调节迁移细胞前端整合素聚集以及黏着斑的形成（1,2）。研究证明PVR和nectin-3调节转化3T3细胞运动和增殖时的接触抑制（3）。更多的研究指出PVR (CD155, Necl-5)的表达可能在肺癌的侵袭过程中发挥了功能（4,5）。在免疫系统中，CD155在天然杀伤细胞（NK）介导的细胞毒性作用中也扮演了一定角色（6）。 |
| 存放说明 | -20C |
| 计算分子量 | 80-90 glycosylated 45-50 nonglycosylated |
参考图片Western blot analysis of extracts from various cell lines using PVR/CD155 (D3G7H) Rabbit mAb (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower).使用PVR/CD155 (D3G7H) Rabbit mAb (上) 或α-Actinin (D6F6) XP® Rabbit mAb #6487 (或)对多种细胞提取物进行western blot分析。 |
Western blot analysis of extracts from HeLa cells, untreated (lane 1; -), mock treated (lane 2; -), or peptide-N-glycosidase F (PGNaseF)-treated (lane 3; +), using PVR/CD155 (D3G7H) Rabbit mAb (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower).未处理(lane 1; -),模拟处理(lane 2; -),或peptide-N-glycosidase F (PGNaseF)-处理(lane 3; +)的HeLa细胞提取物，使用PVR/CD155 (D3G7H) Rabbit mAb(上)或α-Actinin (D6F6) XP® Rabbit mAb #6487 (下)进行western blot分析。 |
