Rab25 (D3H4N) Rabbit mAb
货号：
13081S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13081S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Rab11a, Rab11b, and Rab25 are members of the Rab11 subfamily of small Ras-like GTPases. Unlike universally expressed Rab11, typical Rab25 expression appears to be limited to gastrointestinal mucosa, kidney, and lung (1). Rab25 can associate with apical recycling vesicles to help regulate apical vesicle trafficking (2,3). Research studies indicate that atypical Rab25 expression can be associated with various forms of cancer. Increased Rab25 expression is associated with aggressive growth in ovarian and breast cancer, where Rab25 may inhibit apoptosis and promote cancer cell proliferation and invasion through regulation of vesicle transport and cellular motility (4-7). Interaction between Rab25 and β1 integrin promotes vesicle-mediated transport of integrin to pseudopodial tip membranes, fostering the persistent invasion of tumor cells (8). Conversely, the reported loss of Rab25 expression in a number of breast cancer cases has an unclear effect on cancer pathogenesis (9). |
| 存放说明 | -20C |
| 计算分子量 | 23 |
参考图片Western blot analysis of extracts from HCT-15, ZR-75-1, and MCF7 cells using Rab25 (D3H4N) Rabbit mAb.使用Rab25 (D3H4N) Rabbit mAb对HCT-15, ZR-75-1, 和MCF7细胞提取物进行western blot分析。 |
