Rab3A (D7B10) Rabbit mAb
货号：
12214S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12214S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Rab3A (D7B10) Rabbit mAb recognizes endogenous levels of total Rab3A protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The Rab family of proteins includes small, monomeric GTPases essential for regulating intracellular vesicle trafficking. Members of the Rab3 subfamily, including Rab3A-3D, are involved in the exocytosis of neurotransmitters and hormones (1). Rab3A is primarily expressed in neurons (2), neuroendocrine cells (such as rat PC-12 cells), and in human pancreatic β cells (3,4). By acting as a molecular switch between active GTP-bound Rab3A and the inactive GDP-bound form, Rab3A inhibits synaptic vesicle and chromaffin granule secretion during late membrane release (5,6). Loss-of-function studies suggest Rab3A is involved in controlling synaptic vesicle targeting and docking at the active zone (7). Through binding to its direct effector Rabphillin, Rab3A also orchestrates the coupling between synaptic vesicle exocytosis and endocytosis (8). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
参考图片Western blot analysis of extracts from various cell lines using Rab3A (D7B10) Rabbit mAb. Western blot方法检测多种细胞系的提取物，使用的抗体为 Rab3A (D7B10) Rabbit mAb兔单抗。 |
