RAG1 (D36B3) Rabbit mAb
货号：
3968S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3968S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | RAG1 (D36B3) Rabbit mAb detects endogenous levels of total RAG1 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some cases a D (Diversity) segment, to create the antigen-binding portion of the receptor. The recombined V(D)J segment is then spliced into exons that encode the constant region to produce mature mRNA (1,2). This essential process required for the development of functional immune T and B cells creates a vast diversity in these receptors (3,4). Initiation of this process follows binding of RAG1 (recombination activating gene 1) and RAG2 to the conserved recombination signal sequences (RSS) and the introduction of a double-strand break between the RSS and the coding sequence (5,6). RAG1 and RAG2 genes are located immediately adjacent to each other in the genome and lack introns in their coding regions in many species. RAG1 and RAG2 are coexpressed only in the B and T cell lineages and both are required for cleavage activity (7). RAG1 and RAG2 can also function as transposases, contributing to chromosomal translocations and lymphoid malignancy (8,9). Mutations in the RAG genes are associated with a spectrum of combined immune deficiencies in humans (10,11). |
| 存放说明 | -20C |
| 计算分子量 | 119 |
参考图片Western blot analysis of extracts from MOLT-4 and HBP-ALL cells using RAG1 (D36B3) Rabbit mAb.Western免疫印迹。用RAG1 (D36B3) Rabbit mAb研究MOLT-4和HBP-ALL细胞的细胞提取液。 |
