RAGE 1 (D1A12) Rabbit mAb
货号：
6996S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6996S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RAGE 1 (D1A12) Rabbit mAb recognizes endogenous levels of total RAGE 1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The receptor for advanced glycation end products (RAGE) is member of the immunoglobulin (Ig) superfamily. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a secreted sRAGE protein that lacks a transmembrane domain (1). RAGE is detected during early developmental stages and in the lung under normal physiological conditions (2) and is upregulated at sites of inflammation (3). Advanced glycation end products (AGEs) and a variety of other ligands interact with this receptor (1). Ligand binding activates full-length RAGE and initiates downstream signaling pathways that include activation of NF-κB, which leads to production of pro-inflammatory cytokines and inflammation (4). Activation of these pathways has been implicated in various disease states including Alzheimer disease, diabetes, arthritis, and atherosclerosis (4). Soluble RAGE can competitively bind RAGE ligands in the extracellular environment, which prevents ligand interaction with full-length RAGE at the cell surface (1). |
| 存放说明 | -20C |
| 计算分子量 | 55 |
参考图片Western blot analysis of extracts from human lung tissue using RAGE 1 (D1A12) Rabbit mAb.Western免疫印迹。用RAGE 1 (D1A12) Rabbit mAb研究人肺组织的提取液。 |
