Rap1A/Rap1B (26B4) Rabbit mAb
货号：
2399S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2399S |
| 反应种属 | Human/Mouse/Rat/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Rap1 (26B4) Rabbit mAb detects endogenous levels of total Rap1A and Rap1B protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels (1,2). Like other small GTPases, Rap activity is stimulated by guanine nucleotide exchange factors (GEF) and inactivated by GTPase activating proteins (GAP). A wide variety of Rap GEFs have been identified: C3G connects Rap1 with RTKs through adaptor proteins such as Crk, Epacs (or cAMP-GEFs) transmit signals from cAMP, and CD-GEFs (or CalDAG-GEFs) convey signals from either or both Ca2+ and DAG (1). Rap1 primarily regulates multiple integrin-dependent processes such as morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration and tumor invasion (1,2). Rap1 may also regulate proliferation, differentiation and survival through downstream effectors including B-Raf, PI3K, RalGEF and phospholipases (PLCs) (1-4). Rap1 and Rap2 are not fuctionally redundant as they perform overlapping but distinct functions (5). Recent research indicates that Rap2 regulates Dsh subcellular localization and is required for Wnt signaling in early development (6). |
| 存放说明 | -20C |
| 计算分子量 | 21 |
参考图片Western blot analysis of extracts from various cell lines, using Rap1A/Rap1B (26B4) Rabbit mAb. 使用Rap1A/Rap1B (26B4) Rabbit mAb兔单抗，免疫印迹（Western Blot）分析不同细胞中Rap1A/Rap1B蛋白水平。 |
