Ras (D2C1) Rabbit mAb
货号：
8955S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8955S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms (1). Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway (2-4). GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway (5). The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 21 |
参考图片Western blot analysis of extracts from various cell lines using Ras (D2C1) Rabbit mAb.使用Ras (D2C1) Rabbit mAb对多种细胞提取物进行western blot分析。 |
