RasGRP3 (C33A3) Rabbit mAb
货号：
3334S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3334S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RasGRP3 (C33A3) Rabbit mAb detects endogenous levels of total RasGRP3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Lymphocyte activation occurs in part through activation of the Ras signaling pathway following lymphocyte receptor stimulation. The RasGRP family of guanine nucleotide exchange factors (GEFs) catalyzes the exchange of GDP for GTP on Ras family small GTPases, promoting their active GTP-bound form. Diacylglycerol (DAG) or phorbol ester binding to RasGRP family members causes their translocation to the cell membrane and stimulates their activity (1,2). While T-Cells express RasGRP1, B-cells express both RasGRP1 and RasGRP3. RasGRP3 is important in linking B-cell receptor (BCR) activation to Ras signaling (3). In response to BCR stimulation, RasGRP3 is phosphorylated at Thr133 by PKC. This phosphorylation event further activates RasGRP3 in response to DAG, which stimulates PKC activity (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
参考图片Western blot analysis of extracts from various cell types using RasGRP3 (C33A3) Rabbit mAb. 使用RasGRP3 (C33A3) Rabbit mAb，免疫印迹（Western Blot）分析不同细胞中RasGRP3蛋白水平。 |
