RBAP46/RBAP48 (D4F8) Rabbit mAb
货号：
9067S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 9067S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RBAP46/RBAP48 (D4F8) Rabbit mAb recognizes endogenous levels of total RBAP46 and RBAP48 proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Retinoblastoma-associated proteins 46 and 48 (RBAP46 and RBAP48; also known as RBBP7 and RBBP4) were first characterized in human cells as proteins that bind to the retinoblastoma (Rb) tumor suppressor protein (1). Since then, these proteins have been shown to be components of many protein complexes involved in chromatin regulation, including the chromatin assembly factor 1 (CAF-1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin assembly during DNA replication (2,3). RBAP46 and RBAP48 are also found in the nucleosome remodeling factor complex NURF, the nucleosome remodeling and histone de-acetylation complex NuRD, and the Sin3/HDAC histone de-acetylation complex (4-7). More recently, RBAP46 and RBAP48 were identified as components of the polycomb repressor complex PRC2, which also contains EED and Ezh2 (8). RBAP46 and RBAP48 bind to the histone fold region of histone H4 and are believed to target these chromatin remodeling, histone acetylation, and histone de-acetylation complexes to their histone substrates (3). |
| 存放说明 | -20C |
| 计算分子量 | 48 |
参考图片Western blot analysis of extracts from various cell lines using RBAP46/RBAP48 (D4F8) Rabbit mAb. 使用RBAP46/RBAP48 (D4F8) Rabbit mAb兔单抗，免疫印迹(Western blot)分析不同细胞中RBAP46/RBAP48蛋白水平。 |
