RECK (D8C7) Rabbit mAb
货号：
3433S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3433S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RECK (D8C7) Rabbit mAb detects endogenous levels of total RECK protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | RECK (reversion-inducing cysteine-rich protein with Kazal motif) is a GPI-anchored membrane glycoprotein that negatively regulates members of the matrix metalloproteinase (MMP) family and functions as a suppressor of transformation (1,2). Its function in MMP inhibition makes RECK a crucial factor in the regulation of extracellular matrix formation and stability during development (2-4). RECK has also been linked to the regulation of other extracellar matrix proteases such as ADAM10 and CD13 and functions in modulating target protein endocytosis and Notch signaling (5,6). RECK is widely expressed in normal tissue and decreased expression of RECK due to promoter methylation has been correlated with tumor transformation, angiogenesis and metastasis (1,7-9). Therefore, loss of RECK expression serves as a prognostic hallmark for cancer malignancy (10,11). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
参考图片Western blot analysis of extracts from various cell lines using RECK (D8C7) Rabbit mAb.使用RECK（D8C7）兔单抗对多种细胞提取物进行western blot分析。 |
