RecQL5 (1A2) Mouse mAb
货号：
5847S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5847S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:100) |
性能| 供应商 | CST |
| 背景 | The RecQ family is a group of DNA helicases that play an important role in global genomic stability (1). Mutations in three of the five known human RecQ proteins (BLM, WRN, and RECQL4) give rise to clinically distinct disorders that are characterized by features such as premature aging and predisposition to cancer (2,3). The clinical distinction of each disease associated with these mutations points to distinct roles that members of this helicase family play in DNA metabolism. The RecQL5 helicase has not yet been associated with any human disease, but RecQL5 -/- mice exhibit an increased incidence of cancer (4,5). It has recently been shown that RecQL5 protects genome stability through two parallel mechanims: helicase action and interaction with the initiation form of RNA Polymerase II (6). It has also been shown that RecQL5 -/- mouse embryonic stem cells display an elevated frequency of sister chromatic exchange (SCE), suggesting a role in suppression of homologous recombination and/or crossover events (7,8).RecQ家族是一组DNA解旋酶，在整体基因组稳定性过程中发挥着重要作用(1)。五个已知的RecQ蛋白中的三个(BLM，WRN和RECQL4)发生突变会引起临床上不同的功能紊乱如早衰和癌症易感性(2,3)。与这些突变点相关疾病的不同临床表型表明该解旋酶家族的成员在DNA代谢中具有特殊的作用。至今未发现和RecQL5解旋酶相关的疾病，但是RecQL5基因敲除小鼠的癌症发生率升高(4,5)。最近研究表明RecQL5能够以两种平行的机制-解旋酶功能和与RNA 聚合酶 II的起始形式相互作用-来保护基因组稳定性(6)。亦有研究发现RecQL5基因敲除的小鼠胚胎干细胞呈现频率升高的姐妹染色单体交换(SCE)，表明了其抑制同源重组和(或)交叉事件的功能(7,8)。 |
| 存放说明 | -20C |
| 计算分子量 | 120 |
参考图片Western blot analysis of extracts from Daudi and 293 cells using RecQL5 (1A2) Mouse mAb.Western blot 方法检测Daudi 和293细胞的提取物，使用抗体为RecQL5 (1A2) Mouse mAb。 |
