RhoE (4) Mouse mAb
货号：
3664S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3664S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | RhoE (4) Mouse mAb detects endogenous levels of total RhoE protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Rho family small GTPases act as molecular switches that regulate processes such as cell migration, adhesion, proliferation and differentiation. Typically, they are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and are inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP (1). Rnd1, Rnd2 and RhoE/Rnd3 comprise the evolutionarily divergent Rnd family of Rho-type small GTPases, which lack GTPase activity and therefore remain in a GTP-bound state (2, reviewed in 3). RhoE/Rnd3 activity leads to a decrease in stress fibers and increased cell migration, at least in part through regulation of the Rho-dependent kinase ROCK1 (4). Activity of RhoE/Rnd3 itself is regulated by ROCK1, which phosphorylates RhoE/Rnd3 at Ser11, enhancing its activity (5). RhoE/Rnd3 has been implicated in inhibition of DNA-damage induced apoptosis (6) and cell cycle arrest (7). In keratinocytes, RhoE/Rnd3 regulates differentiation through its effects on both proliferation and adhesion (8). |
| 存放说明 | -20C |
| 计算分子量 | 29 |
参考图片Western blot analysis of extracts from various cell types using RhoE (4) Mouse mAb. 使用RhoE (4) Mouse mAb，免疫印迹（Western Blot）分析不同细胞中RhoE蛋白水平。 |
