| 货号 | 53424S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP |
| 目标/特异性 | CLIC1 (D7D6H) Rabbit mAb recognizes endogenous levels of total CLIC1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Chloride intracellular channel (CLIC) proteins belong to a family of highly conserved transport proteins found as both soluble and membrane-bound forms (1). Although CLIC proteins have putative, selective chloride ion channel activity, they are structural homologs to members of the glutathione-S-transferase protein superfamily and are likewise regulated by redox status (2). CLIC proteins are distinct from other ion channels in that they are found as both soluble and integral membrane forms, and their form determines their function (3-6). Chloride intracellular channel proteins are ubiquitously expressed in numerous tissue types and are involved in diverse biological functions (1,2). |
| 存放说明 | -20C |
| 计算分子量 | 22 |
| 参考文献 | 1 . Littler, D.R. et al. (2010) FEBS Lett 584, 2093-101. 2 . Oakley, A.J. (2005) Curr Opin Struct Biol 15, 716-23. 3 . Littler, D.R. et al. (2005) FEBS J 272, 4996-5007. 4 . Singh, H. and Ashley, R.H. (2006) Biophys J 90, 1628-38. 5 . Suh, K.S. et al. (2004) J Biol Chem 279, 4632-41. 6 . Fernández-Salas, E. et al. (2002) Mol Cell Biol 22, 3610-20. 7 . Ulmasov, B. et al. (2007) BMC Cell Biol 8, 8. 8 . Wei, X. et al. (2015) J Gastroenterol Hepatol 30, 208-16. 9 . Gurski, L.A. et al. (2015) Mol Cancer Res 13, 273-80. 10 . Ding, Q. et al. (2015) Tumour Biol 36, 193-8. 11 . Tian, Y. et al. (2014) Cancer Biother Radiopharm 29, 339-44. 12 . Novarino, G. et al. (2004) J Neurosci 24, 5322-30. 13 . Milton, R.H. et al. (2008) J Neurosci 28, 11488-99. |
Immunoprecipitation of CLIC1 from C2C12 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is CLIC1 (D7D6H) Rabbit mAb. Western blot analysis was performed using | |
Western blot analysis of extracts from K-562, MDA-MB-231, and C2C12 cells using CLIC1 (D7D6H) Rabbit mAb. |
