Ron (C81H9) Rabbit mAb
货号：
2654S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2654S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Ron (C81H9) Rabbit mAb detects endogenous levels of the β chain of Ron protein. This antibody does not cross-react with other family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements (1,2). Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis. The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival (3,4). The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors (5). |
| 存放说明 | -20C |
| 计算分子量 | 145 and 150 |
参考图片Western blot analysis of BxPC-3 cell extracts using Ron (C81H9) Rabbit mAb.用 Ron (C81H9) Rabbit mAb对BxPC-3细胞的提取物进行免疫印迹检测。 |
