ROS1 (69D6) Mouse mAb
货号：
3266S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3266S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | Ros (69D6) Mouse mAb detects endogenous levels of total Ros protein. This antibody does not cross-react with other related proteins. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | The c-ros proto-oncogene encodes a receptor tyrosine kinase similar to insulin receptor proteins and expressed in specific epithelial cells (1). During mouse development the Ros receptor plays an important role in the differentiation of epididymal epithelium (2). Overexpression or mutation of Ros may lead to oncogenic development. Furthermore, stable transfection with a chimeric receptor containing the Ros transmembrane and cytoplasmic domains leads to transformation of NIH/3T3 fibroblasts (3). A genetic rearrangement that produces a fusion protein containing Ros and FIG (fused in glioblastoma) results in glioblastoma formation (4). The FIG-Ros fusion abnormally activates the SHP-2 phosphatase and PI3K/Akt/mTOR pathways in tumor cells (5). Additional Ros mutations are associated with NSCLC cancer cells indicating that Ros may be a candidate for tumor targeted therapy (6). |
| 存放说明 | -20C |
| 计算分子量 | 258, 110, 50-80 |
参考图片Western blot analysis of extracts from HCC78 cells using Ros (69D6) Mouse mAb. HCC78 cells express several Ros translocation forms where a Ros fragment is fused with a SLC34A2 protein fragment. The molecular weight of fusion proteins shown are 85 kDa, 70 kDa and 59 kDa (Rikova, K. et al. (2007) Cell 131, 1190-1203).用Ros (69D6) Mouse mAb 对 HCC78 细胞的裂解液进行免疫印迹检测。 HCC78 cells 表达多种Ros和SLC34A2蛋白片段融合后的Ros移位形式。融合蛋白的分子量是85 kDa、 70 kDa 和59 kDa (Rikova, K. et al. (2007) Cell 131, 1190-1203)。 |
