| 货号 | 9647S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | RUNX3/AML2 (D6E2) Rabbit mAb recognizes endogenous levels of both isoforms of RUNX3 protein. This antibody does not recognize RUNX1 and RUNX2 proteins. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | RUNX3/AML2 is a member of the Runt family of transcription factors. RUNX3 is important for the suppression of cell proliferation in the gastric epithelium (1), neurogenesis of the dorsal root ganglia (2), and T cell differentiation (3,4). According to the research literature, RUNX3 is found to be inactivated in more than 80% of gastric cancers and other cancer types by gene silencing or protein mislocalization (1,5,6). The tumor suppressor function of RUNX3 is exerted by forming complexes with various transcription factors, such as Smads or β-Catenin/TCF4 to regulate downstream target gene transcription (7,8). RUNX3 is also involved in caspase-3-dependent apoptosis (9). RUNX3 is normally located in the nucleus, however, in many cancer cells, RUNX3 is tyrosine phosphorylated and mislocated to the cytoplasm. The mislocation of RUNX3 abolishes its tumor suppressor function and contributes to tumorigenesis (10). |
| 存放说明 | -20C |
| 计算分子量 | 43-48 |
Western blot analysis of extracts from SW620 and HeLa cells using RUNX3/AML2 (D6E2) Rabbit mAb. 使用RUNX3/AML2 (D6E2) Rabbit mAb兔单抗对SW620 和HeLa 细胞提取物进行Western blot分析。 |
