S100B (D10G6) Rabbit mAb
货号：
9550S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 9550S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | S100B (D10G6) Rabbit mAb recognizes endogenous levels of total S100B protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Despite their relatively small size (8-12 kDa) and uncomplicated architecture, S100 proteins regulate a variety of cellular processes such as cell growth and motility, cell cycle progression, transcription, and differentiation. To date, 25 members have been identified, including S100A1-S100A18, trichohyalin, filaggrin, repetin, S100P, and S100Z, making it the largest group in the EF-hand, calcium-binding protein family. Interestingly, 14 S100 genes are clustered on human chromosome 1q21, a region of genomic instability. Research studies have demonstrated significant correlation exists between aberrant S100 protein expression and cancer progression. S100 proteins primarily mediate immune responses in various tissue types but are also involved in neuronal development (1-4).
Each S100 monomer bears two EF-hand motifs and can bind up to two molecules of calcium (or other divalent cation in some instances). Structural evidence shows that S100 proteins form antiparallel homo- or heterodimers that coordinate binding partner proximity in a calcium-dependent (and sometimes calcium-independent) manner. Although structurally and functionally similar, individual members show restricted tissue distribution, are localized in specific cellular compartments, and display unique protein binding partners that suggest each plays a specific role in various signaling pathways. In addition to an intracellular role, some S100 proteins have been shown to act as receptors for extracellular ligands or are secreted and exhibit cytokine-like activities (1-4). |
| 存放说明 | -20C |
| 计算分子量 | 10 |
参考图片Western blot analysis of extracts from mouse brain, C2C12 cells, rat brain, and C6 cells using S100B (D10G6) Rabbit mAb (upper) and α/β-Tubulin Antibody #2148 (lower). Western blot方法检测小鼠脑组织、C2C12细胞、大鼠脑组织和C6细胞提取物，使用的抗体为S100B (D10G6) Rabbit mAb (上图) 和α/β-Tubulin Antibody #2148 (下图). |
