Sall4 (D16H12) Rabbit mAb
货号：
8459S 基本售价：
3360.0 元 规格：
100ul
产品信息
概述| 货号 | 8459S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IF-IC |
| 使用方法 | WB(1:1000)
IF-IC (1:100) |
性能| 供应商 | CST |
| 背景 | Members of the SALL gene family encode putative zinc finger transcription factors highly expressed during development (1). Sall4 is expressed very early in development with other pluripotency regulators, such as Oct4 and Nanog (2). Recent studies suggest Sall4 works as a master regulator that controls its own expression and the expression of Oct4 in a transcriptional regulation feedback loop governing stem cell pluripotency and stem cell fate (2,3). Immunohistochemical studies indicate that Sall4 is a sensitive and specific diagnostic marker for primary germ cell tumors and yolk sac tumors (4,5). Sall4 has also been shown to be contstitutively expressed in AML and is a probable effector of the Wnt/β-catenin signaling pathway in this disease (6). Mutations in Sall4 are implicated in human malformation syndromes including Duane-radial ray syndrome (Okhiro syndrome) and acro-renal-ocular syndrome (7). |
| 存放说明 | -20C |
| 计算分子量 | 80, 142 |
参考图片Confocal immunofluorescent analysis of NTERA-2 (left) and HeLa cells (right) using Sall4 (D16H12) Rabbit mAb (green). Actin filaments were labeled with DY-554 phalloidin (red). |
