SENP1 (D16D7) Rabbit mAb
货号：
11929S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11929S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SENP1 (D16D7) Rabbit mAb recognizes endogenous levels of total SENP1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | SENP1 is a member of the sentrin/SUMO-specific protease (SENP) family. SENP1 localizes to the nucleoplasm and catalyzes the release of SUMO1, SUMO2, and SUMO3 monomers from sumoylated substrates (1,2). SENP1 has been reported to be responsible for intracellular SUMO homeostasis in the control of normal cellular function (2). The removal of sumoylation by SENP1 from many important target proteins, such as HDAC1, HIF-1α, Stat5, p300, Elk-1, and SirT1, leads to the regulation of the related biological pathways (3-8). SENP1-induced desumoylation of HIF-1α stabilizes the target during hypoxia (5), activating downstream VEGF expression and angiogenesis (9). SENP1 desumoylates Stat5 and contributes to Stat5 acetylation and subsequent signaling during normal lymphocyte development (6). Under stress conditions, SENP1 interacts with and inactivates SirT1 by desumoylation, protecting cells from apoptosis (8). SENP1 has been reported to target the progesterone and androgen receptors, either directly or indirectly through HDAC1, thereby upregulating their transcriptional function and potentially affecting receptor-related cancer progression (3,10-13). |
| 存放说明 | -20C |
| 计算分子量 | 76 |
参考图片Western blot analysis of extracts from 293, A-204, and PANC-1 cells using SENP1 (D16D7) Rabbit mAb. Western blot检测293、A-204和PANC-1细胞提取物，采用SENP1 (D16D7) Rabbit mAb。 |
