SFRP1 (D5A7) Rabbit mAb
货号：
3534S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3534S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SFRP1 (D5A7) Rabbit mAb detects endogenous levels of total SFRP1 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Secreted Frizzled-related proteins (SFRPs) display homology and structural similarity to the extracellular cysteine-rich Wnt-binding domain of the G protein-coupled receptor Frizzled (1,2). To date, five distinct SFRPs (SFRP1 to 5) have been found in mammalian cells. These secreted proteins typically act as antagonists to Wnt signaling by directly binding and inhibiting Wnt proteins, or by binding Frizzled to block Wnt protein interaction with the receptor (3). The various SFRPs bind and regulate Wnt proteins differentially; these proteins also display distinct expression patterns as they play important roles in regulating development (4-7). SFRP proteins appear to act as tumor suppressors, with loss of expression or function correlating with many invasive forms of cancer. Deletion of the corresponding SFRP1 gene and promoter hypermethylation leading to gene silencing has been reported in a number of cancers. Abnormal expression of SRFP1 and other Wnt signaling proteins is associated with some cases of retinitis pigmentosa (reviewed in 8). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
参考图片Western blot analysis of extracts from various cell types using SFRP1 (D5A7) Rabbit mAb.使用SFRP1 (D5A7) 兔单抗对多种细胞提取物进行western blot分析。 |
