SHP-1 (C14H6) Rabbit mAb
货号：
3759S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3759S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SHP-1 (C14H6) Rabbit mAb detects endogenous level of total SHP-1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain and a carboxy-terminal regulatory domain (1). SHP-1 removes phosphates from target proteins to down regulate several tyrosine kinase regulated pathways. In hematopoietic cells, the N-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth (2). Over expression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation (3). Following ligand binding in myeloid cells, SHP-1 associates with IL-3R β chain and down regulates IL-3-induced tyrosine phosphorylation and cell proliferation (4). Because SHP-1 down regulates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regulator (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 68 |
参考图片Western blot analysis of extracts from Jurkat, 32D and BaF3 cells using SHP-1 (C14H6) Rabbit mAb.Western免疫印迹。用SHP-1 (C14H6) Rabbit mAb研究 Jurkat, 32D 和 BaF3 细胞的细胞提取液。 |
