SINTBAD (D1A5) Rabbit mAb
货号：
8605S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8605S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SINTBAD (D1D5) Rabbit mAb recognizes endogenous levels of total SINTBAD protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | SINTBAD, identified based on homology to NAP1, is an adaptor protein for TBK1 and IKKε, two related kinases that play a pivotal role in innate immune response (1). These kinases trigger the phosphorylation and subsequent activation of the transcription factor IRF-3, resulting in gene regulation required for immune responses (2). The precise mechanism by which SINTBAD activates TBK1 and IKKε is still unclear. Expression of a central region of SINTBAD termed a TBD (TBK binding domain) can function as a dominant negative protein and interfere with IRF-3 activation. SINTBAD and NAP1 can also bind to NDP52, a protein that associates with poly-ubiquitinated proteins, such as those produced on the surfaces of bacteria, and can trigger autophagy (3). |
| 存放说明 | -20C |
| 计算分子量 | 78-80 |
参考图片Western blot analysis of extracts from various cell lines and tissues using SINTBAD (D1A5) Rabbit mAb.Western免疫印迹。用SINTBAD (D1A5) Rabbit mAb研究各种细胞和组织的提取液。 |
