SirT6 (D10A4) Rabbit mAb
货号：
8771S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8771S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SirT6 (D10A4) Rabbit mAb recognizes endogenous levels of total SirT6 protein. This antibody does not cross-react with other sirtuin proteins. This antibody detects a non-specific protein at 70 kDa of unknown origin. |
| 使用方法 | WB(1:1000)
IP (1:200) |
性能| 供应商 | CST |
| 背景 | The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging (1). SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway (2-4). The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2 (2). In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps (2). SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway (2). |
| 存放说明 | -20C |
| 计算分子量 | 42 |
参考图片Western blot analysis of extracts from HCT 116, 293, and K-562 cells using SirT6 (D10A4) Rabbit mAb.Western blot方法检测HCT116，293以及K-562细胞提取物，使用的抗体为SirT6 (D10A4) Rabbit mAb。 |
