SMARCA1 (D4Q7V) Rabbit mAb【科瑞奥博】

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SMARCA1 (D4Q7V) Rabbit mAb

货号： 12483S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	12483S
反应种属	Human/Monkey
来源宿主	Rabbit
应用	W/IP
目标/特异性	SMARCA1 (D4Q7V) Rabbit mAb recognizes endogenous levels of total SMARCA1 protein.
使用方法	WB(1:1000) IP (1:100)

性能
供应商	CST
背景	SMARCA1 (SNF2L) is one of the two orthologs of the ISWI (imitation switch) ATPases encoded by the mammalian genome (1). The ISWI chromatin remodeling complexes were first identified in Drosophila and have been shown to remodel and alter nucleosome spacing in vitro (2). SMARCA1 is the catalytic subunit of the nucleosome remodeling factor (NURF) and CECR2-containing remodeling factor (CERF) complexes (3-5). The NURF complex plays an important role in neuronal physiology by promoting neurite outgrowth and regulation of Engrailed homeotic genes that are involved in neuronal development in the mid-hindbrain (3). NURF is also thought to be involved in the maturation of T cells from thymocytes by regulating chromatin structure and expression of genes important for T cell development (6). The largest subunit of the NURF complex, BPTF, is required for proper development of mesoderm, endoderm, and ectoderm tissue lineages, suggesting a role for SMARCA1 in the development of the germ layers in mouse embryo (7). Disruption of the CERF complex by deletion of CECR2, an interacting partner of SMARCA1, is associated with the neural tube defect exencephaly, linking the CERF complex with regulation of neurulation (4).
存放说明	-20C
计算分子量	130

参考图片

Western Blot anaylsis of extracts from various cell lines using SMARCA1 (D4Q7V) Rabbit mAb.Western blot方法检测多种细胞系的提取物，使用的抗体为SMARCA1 (D4Q7V) Rabbit mAb。

Immunoprecipitation of SMARCA1 from PANC-1 cell extracts using Rabbit (DA1E) IgG XP® Isotype Control #3900 (lane 2) or SMARCA1 (D4Q7V) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using SMARCA1 (D4Q7V) Rabbit mAb.从 PANC-1细胞提取物中免疫沉淀SMARCA1，使用的抗体为Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane2)或SMARCA1 (D4Q7V) Rabbit mAb (lane 3)。Lane 1为10% input。使用SMARCA1 (D4Q7V) Rabbit mAb进行Western blot检测。