Snail (L70G2) Mouse mAb
货号：
3895S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3895S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | Snail (L70G2) Mouse mAb detects endogenous levels of total Snail protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function (7-10). |
| 存放说明 | -20C |
| 计算分子量 | 29 |
参考图片Western blot analysis of extracts from HCT-116, NIH/3T3 and Rat2 cells using Snail (L70G2) Mouse mAb.使用Snail （L70G2）鼠单抗对HCT-116，NIH/3T3和Rat2细胞提取物进行进行western blot分析。 |
