Snail (SN9H2) Rat mAb
货号：
4719S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4719S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rat IgG2a |
| 应用 | W |
| 目标/特异性 | Snail (SN9H2) Rat mAb detects endogenous levels of total Snail. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function (7-10). |
| 存放说明 | -20C |
| 计算分子量 | 29 |
参考图片Western blot analysis of total cell lysates from HCT116, 293 cells, and 293 cells transiently transfected with a SNAIL expressing construct, using Snail (SN 9H2) Rat mAb.HCT116，293细胞以及经过SNAIL表达质粒瞬时转染的293细胞提取物进行Western blot实验，使用Snail (SN 9H2) 兔源单克隆抗体检测。 |
