SOS1 (D3T7T) Rabbit mAb
货号：
12409S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12409S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Son of sevenless (SOS) was first identified in Drosophila as a guanine nucleotide exchange factor (GEF) for Ras acting downstream of the Sevenless receptor (1). Two closely related homologs of Drosophila SOS are found in mammalian cells: SOS1 and SOS2 (2). SOS1 consists of histone folds, Dbl (DH) and pleckstrin (PH) homology domains, a Ras exchange motif (REM), and Cdc25 homology and polyproline domains (3). SOS1 binds to GRB2, NCK, and other adaptor proteins, and plays an important role in ERK activation downstream of protein tyrosine kinase receptor (RTK). Research studies have identified mutations in the corresponding SOS1 gene of patients with Noonan syndrome, a developmental disorder characterized by short stature, facial dysmorphia, and congenital heart defects (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 152 |
参考图片Western blot analysis of extracts from various cell lines using SOS1 (D3T7T) Rabbit mAb.使用SOS1 (D3T7T)Rabbit mAB对多种细胞提取物进行western blot分析。 |
