| 货号 | 65650S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | Arg3.1 (D6H9N) Rabbit mAb recognizes endogenous levels of total Arg3.1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Arg3.1, also known as Arc for activity-regulated cytoskeleton-associated protein, is an immediate early gene whose expression is necessary for synaptic plasticity (1). Arg3.1 expression is induced by many experimental stimuli such as LTP (2), LTD (3), and learning. Arg3.1 is also involved in the regulation of synaptic strength and homeostatic scaling by promoting AMPA receptors endocytosis (5,6). Arg3.1 dysregulation has been proposed to participate in cognitive decline during aging (7). |
| 存放说明 | -20C |
| 计算分子量 | 51 |
| 参考文献 | 1 . Guzowski, J.F. et al. (1999) Nat Neurosci 2, 1120-4. 2 . Lyford, G.L. et al. (1995) Neuron 14, 433-45. 3 . Guzowski, J.F. et al. (2000) J Neurosci 20, 3993-4001. 4 . Guzowski, J.F. et al. (2001) J Neurosci 21, 5089-98. 5 . Chowdhury, S. et al. (2006) Neuron 52, 445-59. 6 . Rial Verde, E.M. et al. (2006) Neuron 52, 461-74. 7 . Fletcher, B.R. et al. (2014) Neurobiol Learn Mem 115, 58-67. |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human Arg3.1 (hArg3.1-Myc/DDK; +), and extracts from SK-N-MC cells using Arg3.1 (D6H9N) Rabbit mAb. |
