| 货号 | 5467S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Synaptophysin (D40C4) Rabbit mAb detects endogenous levels of total synaptophysin protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). |
| 存放说明 | -20C |
| 计算分子量 | 38 |
Western blot analysis of extracts from mouse and rat brain using Synaptophysin (D40C4) Rabbit mAb. Western blot分析小鼠和大鼠大脑提取物，使用的抗体是Synaptophysin (D40C4)Rabbit mAb 兔单抗。 |
