Synip (C51G6) Rabbit mAb
货号：
2400S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2400S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Synip (C51G6) Rabbit mAb detects endogenous levels of total Synip protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Insulin binds to and activates its receptor and initiates a signaling cascade that eventually induces the translocation of the Glut4 glucose transporter from its intracellular locations to the plasma membrane. Initiating this pathway facilitates glucose uptake in fat and skeletal muscle cells (1). Synip and Syntaxin 4 are two proteins thought to be involved in the recruitment of Glut4-containing vesicles to plasma membrane (2,3). Synip associates with Syntaxin 4 when insulin is absent. Insulin signaling triggers the dissociation of the two proteins and allows Syntaxin 4 to complex with VAMP2, which is essential for Glut4 translocation to plasma membrane (2-4). Overexpression of a dominant-negative form of Synip prevents Glut4 from translocating to plasma membrane in response to insulin stimulation (3). Synip together with Syntaxin 4, therefore, regulates Glut 4 transport to plasma membrane. |
| 存放说明 | -20C |
| 计算分子量 | 62 |
参考图片Western blot analysis of extracts from RD cells using Synip (C51G6) Rabbit mAb. 对RD细胞抽提液使用Synip (C51G6) Rabbit mAb兔单抗进行Western blot分析。 |
