| 货号 | 14241S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | TAK1-binding protein 3 (TAB3) is an additional binding partner for TAK1 and appears to be functionally redundant to TAB2 protein (9,10). The carboxy-terminal zinc finger domains in TAB2 and TAB3 bind to lysine 63-linked polyubiquitin chains within target proteins, including TRAF6, IKKγ, and RIP, which results in activation of IKK (11). Research studies also indicate that TAB2 and TAB3 proteins negatively regulate autophagy through interaction with beclin-1 (12,13). |
| 存放说明 | -20C |
| 计算分子量 | 82 |
Western blot analysis of extracts from various cell lines using TAB3 (D5J7D) Rabbit mAb. | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing full-length mouse TAB3 protein (mTAB3; +), using TAB3 (D5J7D) Rabbit mAb. | |
Western blot analysis of extracts from 293T cells, transfected with 100 nM SignalSilence® Control siRNA (Unconjugated) #6568, SignalSilence® TAB3 siRNA I #14212, or SignalSilence® TAB3 siRNA II #14225, using TAB3 (D5J7D) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The TAB3 (D5J7D) Rabbit mAb confirms silencing of TAB3 expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control. |
