TAK1 (D94D7) Rabbit mAb
货号：
5206S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5206S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein and other cytokines including IL-1 (1,2). In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1 (3,4). Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation (5). Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase (NIK) (2). |
| 存放说明 | -20C |
| 计算分子量 | 78 to 82 |
参考图片Western blot analysis of extracts from various cell lines using TAK1 (D94D7) Rabbit mAb.western blot方法检测细胞提取物：各种细胞系。使用的抗体是AK1 (D94D7) Rabbit mAb |
