| 货号 | 72202S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W IP IHC-P |
| 目标/特异性 | MRP1/ABCC1 (D5C1X) Rabbit mAb recognizes endogenous levels of total MRP1 protein. This antibody does not cross-react with MRP2 and MRP3 proteins. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the MRP subfamily of ATP-binding cassette (ABC) transporters (1). MRP1/ABCC1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agents and the glutathione (GSH) conjugates of these compounds. MRP1/ABCC1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids, leukotrienes, and prostaglandins (2,3). |
| 存放说明 | -20C |
| 计算分子量 | 170-220 |
| 参考文献 | 1 . Cole, S.P. et al. (1992) Science 258, 1650-4. 2 . Pajic, M. et al. (2005) Cancer Lett 228, 241-6. 3 . Deeley, R.G. and Cole, S.P. (2006) FEBS Lett 580, 1103-11. 4 . Atalay, C. et al. (2006) Tumour Biol 27, 309-18. 5 . Sánchez, C. et al. (2011) Prostate 71, 1810-7. 6 . Nooter, K. et al. (1997) Br J Cancer 76, 486-93. 7 . Hsia, T.C. et al. (2002) Lung 180, 173-9. 8 . Kuo, T.H. et al. (2003) Nucl Med Biol 30, 627-32. 9 . Sánchez, C. et al. (2009) Prostate 69, 1448-59. 10 . Vulsteke, C. et al. (2013) Ann Oncol 24, 1513-25. |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using MRP1/ABCC1 (D5C1X) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma using MRP1/ABCC1 (D5C1X) Rabbit mAb. | |
Immunoprecipitation of MRP1/ABCC1 from Hep G2 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is MRP1/ABCC1 (D5C1X) Rabbit mAb. Western blot analysis was performed using MRP1/ABCC1 (D5C1X) Rabbit mAb. | |
Western blot analysis of extracts from PANC-1, A549, and Hep G2 cells using MRP1/ABCC1 (D5C1X) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded SK-MEL-2 (left) and PANC-1 (right) cell pellets using MRP1/ABCC1 (D5C1X) Rabbit mAb. |
