TCF11/NRF1 (D5B10) Rabbit mAb
货号：
8052S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8052S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TCF11/NRF1 (D5B10) Rabbit mAb recognizes endogenous levels of total TCF11 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Transcription factor 11 (TCF11) is a basic leucine zipper transcription factor. It is also referred to as Nuclear factor E2-related factor 1 (NRF1). TCF11 was initially reported to activate erythroid-specific, human globin gene expression (1). It plays an essential role during embryonic development (2). It also associates with other transcription factors, such as Jun proteins, to transcriptionally control antioxidant response element (ARE)-mediated expression in response to antioxidants and xenobiotics (3-5). TCF11 has been shown to regulate proteasomal degradation and mediate the proteasome recovery pathway after proteasome inhibition (6,7). TCF11 is ubiquitously expressed (8) and several isoforms have been reported. The 120 kDa form exists in the endoplasmic reticulum (ER) membrane under normal conditions. Upon proteasome inhibition, TCF11 translocates to the nucleus (9). The 65 kDa N-terminal-truncated form is constitutively localized to the nucleus (10,11). TCF11 protein levels are regulated by ubiquitination and proteasomal-mediated degradation (12); proteasome inhibitors stabilize TCF11. |
| 存放说明 | -20C |
| 计算分子量 | 120-140 |
