| 货号 | 11825S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | TCF12/HEB (D2C10) Rabbit mAb recognizes endogenous levels of total TCF12/HEB protein. This antibody recognizes the TCF12/HEBCan isoform, but not the TCF12/HEBAlt isoform. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | TCF12/HEB (T cell factor 12/HeLa E-box binding protein) is a member of the E proteins that are type I basic helix-loop-helix domain containing transcription factors that bind directly to the E-box DNA consensus sequence and control numerous developmental processes (1,2). E protein family members include E2A, E2-2, and TCF12/HEB. TCF12/HEB forms homo- or heterodimers with other E proteins to regulate transcription of target genes that play a critical role in the development of T cells, B cells, and plasmacytoid dendritic cells (2-4). The TCF12/HEB gene has two transcriptional start sites leading to the generation of the long form called HEBCan, and the short form, HEBAlt (5). The two isoforms are thought to have distinct functions with HEBCan playing a role throughout T cell development, while HEBAlt functions in the efficient generation of T cell precursors (5). |
| 存放说明 | -20C |
| 计算分子量 | 85 |
Western blot analysis of extracts from Jurkat and MOLT-4 cells using TCF12/HEB (D2C10) Rabbit mAb. 使用TCF12/HEB (D2C10)Rabbit mAb兔单抗对Jurkat和MOLT-4细胞提取物进行western blot分析。 |
