| 货号 | 4016S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | TCL1 (1-21) Mouse mAb detects endogenous levels of total TCL1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | TCL1 (T cell leukemia 1), MTCP1 and TCL1b belong to the TCL1 proto-oncogene family, and their products are involved in Akt activation during embryonic development, T cell leukemias, prolymphocytic leukemias and B cell lymphomas (1-3). The Akt association domain of TCL1 binds with the PH domain of Akt. The formation of an oligomeric TCL-Akt complex is required for TCL1 coactivator function and results in phosphorylation and activation of Akt . Furthermore, functional analysis indicates that the interaction between TCL1 and Akt promotes translocation of Akt to the nucleus (4-6). These findings are supported by the crystal structure of TCL1, which suggests that TCL1 may participate in molecular transport (7).TCL1 (T cell leukemia 1), |
| 存放说明 | -20C |
| 计算分子量 | 14 |
Western blot analysis of extracts from Ramos, Raji and Daudi cells, using TCL1 (1-21) Mouse mAb. Western blot分析Ramos, Raji 和Daudi 细胞的提取物，使用的抗体为TCL1 (1-21) Mouse mAb鼠单抗。 |
