TGF-beta Receptor III (D11G10) Rabbit mAb
货号：
5544S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5544S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | TGF-β Receptor III (D11G10) Rabbit mAb detects endogenous levels of total TGF-β Receptor III protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (1-4). TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII) and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases (5). The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain (6,7). Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
参考图片Western blot analysis of extracts from K-562 and C2C12 cells, either untreated or treated with 2% horse serum to induce differentiation into myoblast, using TGF-β Receptor III (D11G10) Rabbit mAb.未处理或经2% 马血清处理诱导分化为肌细胞的k-562细胞和C2C12细胞，获得其细胞提取物，进行western blot实验，使用TGF-β Receptor III (D11G10) 兔单抗检测。 |
