| 货号 | 2429S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | Thioredoxin 1 (C63C6) Rabbit mAb detects endogenous levels of total thioredoxin 1 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:400) |
| 供应商 | CST |
| 背景 | Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond which is then reduced by thioredoxin reductase (1). Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (Trx1) and mitochondrial thioredoxin 2 (Trx2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress and protein reduction (1). A potential role of thioredoxin in human disorders such as cancer, aging and heart disease is currently under investigation (2). Thioredoxin can play a key role in cancer progression, as it acts as a negative regulator of the proapoptotic kinase ASK1 (3) Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 12 |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Thioredoxin 1 (C63C6) Rabbit mAb in the presence of control peptide (left) or Thioredoxin Blocking Peptide #1057 (right). 对石蜡包埋的人乳腺癌使用Thioredoxin 1 (C63C6) Rabbit mAb兔单抗进行免疫组织化学分析，其中左图为对照肽，右图为Thioredoxin阻遏肽#1057。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Thioredoxin 1 (C63C6) Rabbit mAb. 对石蜡包埋的人肺癌使用Thioredoxin 1 (C63C6) Rabbit mAb兔单抗进行免疫组化分析。 | |
Western blot analysis of extracts from various cell types using Thioredoxin 1 (C63C6) Rabbit mAb. 对多个细胞系使用Thioredoxin 1 (C63C6) Rabbit mAb兔单抗进行Western blot分析。 |
