| 货号 | 12373S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IF-F/IF-IC |
| 目标/特异性 | Thyroid Transcription Factor 1 (D2E8) Rabbit mAb recognizes endogenous levels of total thyroid transcription factor 1 protein. |
| 使用方法 | WB(1:1000) IF-F (1:50) IF-IC (1:50) |
| 供应商 | CST |
| 背景 | Thyroid Transcription Factor 1 (TTF1, also known as NKX2-1), a member of the NKX homeobox transcription factor family, was initially discovered in the FRTL-5 rat thyroid cell line (1). Subsequent studies have shown that TTF1 plays an important role in differentiation and morphogensis of the developing thyroid, lung, and ventral forebrain (2). TTF1 controls the expression of several genes, some of which are tissue specific, such as: thyroglobulin, thyroperoxidase, and the thyrotropin receptor in the thyroid; and surfactant proteins and clara cell secretory protein in the lung (2,3). Investigators have found that TTF1 is expressed in malignant tumors of the thyroid and lung, and it is commonly used as a marker for both primary and malignant lung cancers (4-6). |
| 存放说明 | -20C |
| 计算分子量 | 39, 42 |
Confocal immunofluorescent analysis of H441 (left) and A549 (right) cells using Thyroid Transcription Factor 1 (D2E8) Rabbit mAb (green). Actin filaments were labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). 使用甲状腺转录因子1（D2E8）Rabbit mAb（绿色）对H441（左）和A549（右）细胞进行共聚焦免疫荧光分析。肌动蛋白丝使用DY-554phalloidin标记（红色）。蓝色伪彩= DRAQ5® #4084 (DNA荧光染色)。 | |
Confocal immunofluorescent analysis of the hypothalamic region of adult mouse brain using Thyroid Transcription Factor 1 (D2E8) Rabbit mAb (green) and Neurofilament-H (RMdO 20) Mouse mAb #2836 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). 使用甲状腺转录因子1（D2E8）Rabbit mAb兔单抗（绿色）和Neurofilament-H (RMdO 20) Mouse mAb 鼠单抗#2836(红色)对成年小鼠下丘脑进行激光共聚焦免疫荧光分析。蓝色伪彩= DRAQ5® #4084 (DNA荧光染色). | |
