Tie2 (AB33) Mouse mAb
货号：
4224S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4224S |
| 反应种属 | Human/Bovine |
| 来源宿主 | Mouse |
| 应用 | W/IP |
| 目标/特异性 | Tie2 (AB33) Mouse mAb detects endogenous levels of Tie2 in various endothelial cell lines. It does not cross-react with related proteins. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Tie2/Tek is a receptor tyrosine kinase (RTK) expressed almost exclusively on endothelial cells. It is critical for vasculogenesis and could be important for maintaining endothelial cell survival and integrity in adult blood vessels as well as tumor angiogenesis (1-3). A family of ligands known as the angiopoietins binds to Tie2. Interestingly, these ligands appear to have opposing actions, as Angiopoietin-1 (Ang1) and Angiopoietin-4 (Ang4) stimulate tyrosine phosphorylation of Tie2, whereas Angiopoietin-2 (Ang2) and Angiopoietin-3 (Ang3) can inhibit this phosphorylation (4,5). Downstream signaling components, including Grb2, Grb7, Grb14, Shp2, the p85 subunit of phosphatidylinositol 3-kinase and p56/Dok-2, interact with Tie2 in a phosphotyrosine-dependent manner through their SH2 or PTB domains (6,7). Tyr992 is located on the putative activation loop of Tie2 and is a major autophosphorylation site (8). |
| 存放说明 | -20C |
| 计算分子量 | 160 |
参考图片Western blot analysis of extracts from human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells (BAEC), using Tie2 (AB33) Mouse mAb.用Tie2 (AB33) Mouse mAb对人的脐经脉内皮细胞（HUVE）和牛的主动脉内皮细胞（BAEC）的提取物进行免疫印迹检测。 |
