TIMP1 (D10E6) Rabbit mAb
货号：
8946S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8946S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TIMP1 (D10E6) Rabbit mAb recognizes endogenous levels of total TIMP1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function (1,2). In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with α3β1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects (3). TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression (4,5), wound healing, and vascular remodeling (6,7). Mutations in TIMP3 are associated with Sorsbys fundus dystrophy (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 26 |
参考图片Western blot analysis of extracts from various cell lines using TIMP1 (D10E6) Rabbit mAb.使用TIMP1 (D10E6) 兔单抗对多种细胞提取物进行western blot分析。 |
