TIMP3 (D74B10) Rabbit mAb
货号：
5673S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5673S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TIMP3 (D74B10) Rabbit mAb detects endogenous levels of total TIMP3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function (1,2). In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with α3β1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects (3). TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression (4,5), wound healing, and vascular remodeling (6,7). Mutations in TIMP3 are associated with Sorsbys fundus dystrophy (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 20, 25 |
参考图片Western blot analysis of extracts from A-431, NIH/3T3 and COS-7 cells, using TIMP3 (D74B10) Rabbit mAb.使用TIMP3（D74B10）兔单抗对A-431，NIH/3T3和COS-7细胞提取物进行western blot分析。 |
