TORC2/CRTC2 (5B10) Mouse mAb
货号：
13017S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13017S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | TORC2/CRTC2 (5B10) Mouse mAb recognizes endogenous levels of total TORC2/CRTC2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic β-cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes β-cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling (1). The protein CRTC2 (CREB-regulated transcription coactivator 2)/TORC2 (transducer of regulated CREB activity 2) functions as a CREB co-activator (2,3) and is implicated in mediating the effects of these two pathways (4). In quiescent cells, CRTC2/TORC2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of CRTC2/TORC2 and its dissociation from 14-3-3 proteins. Dephosphorylated CRTC2/TORC2 enters the nucleus to promote CREB-dependent transcription. CRTC2/TORC2 plays a key role in the regulation of hepatic gluconeogenic gene transcription in response to hormonal and energy signals during fasting (5). |
| 存放说明 | -20C |
| 计算分子量 | 80 |
参考图片Western blot analysis of extracts from various cell lines using TORC2/CRTC2 (5B10) Mouse mAb. 使用TORC2/CRTC2 (5B10) Mouse mAb鼠单抗对多种细胞提取物进行western blot分析。 |
