Tropomyosin-1/3 (D17B8) Rabbit mAb
货号：
3913S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3913S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Tropomyosin-1/3 (D17B8) Rabbit mAb detects endogenous levels of total tropomyosin-1 and/or tropomyosin-3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Tropomyosin-1 (TPM1) belongs to the high molecular weight members of tropomyosin family (1,2). The protein exists in an alpha-helical coiled-coil conformation and binds multiple acting monomers in a tight manner to stabilize and regulate the actin filament (3). Tropomyosins fullfill functions in muscle and non-muscle cells. In muscle cells, tropomyosins associate with the troponin complex and play a central role in the calcium-dependent regulation of striated muscle contraction in vertebrates. In non-muscle cells, tropomyosins are implicated in the formation and stabilization of cytoskeletal actin filaments to ensure normal cellular processes (1,2). Mutations of tropomysin-1 have been reported as a cause of dilated cardiac myopathies (4). Tropomyosin-1 also functions as a tumor suppressor, and many malignant tumors demonstrate downregulation of tropomyosin-1 expression (5-8). Tropomyosin-1 is phosphorylated at Ser283 through the Erk/DAPK pathway, which promotes stress fiber formation in response to oxidative stress (9-10). |
| 存放说明 | -20C |
| 计算分子量 | 32 , 35, 36, 41 |
参考图片Western blot analysis of extracts from human, mouse and rat heart tissue and C2C12 cells using Tropomyosin-1/3 (D17B8) Rabbit mAb. 使用Tropomyosin-1/3 (D17B8) Rabbit mAb，免疫印迹（Western Blot）分析人源、小鼠和大鼠心脏组织以及C2C12细胞中Tropomyosin-1/3蛋白水平。 |
