TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb
货号：
12029S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12029S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb recognizes endogenous levels of total TRXR2/TXNRD2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Thioredoxin reductases are selenoproteins that are critical for maintaining cellular redox balance and eliminating reactive oxygen species (ROS) (1-4). There are three known mammalian thioredoxin reductases: TRXR1/TXNRD1 (cytosolic), TRXR2/TXNRD2 (mitochondrial), and TRXR3/TXNRD3 (testis-specific) (1). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation (5). TRXR2 is critical for normal heart development and function (1,4). TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice results in congestive heart failure (4). In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy (1). A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk (6). |
| 存放说明 | -20C |
| 计算分子量 | 56 |
参考图片Western blot analysis of extracts from various cell lines using TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb. Western blot 检测多种细胞系提取物，使用抗体为TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb鼠单抗。 |
