| 货号 | 14715S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | The ubiquitously expressed thioredoxin-interacting protein (TXNIP) binds and inhibits thioredoxin to regulate cellular redox state (1-3). Research studies demonstrate that hyperglycemia induces TXNIP expression and increases cellular oxidative stress (1). In addition, these studies show that TXNIP reduces glucose uptake directly by binding the glucose transporter Glut1 to stimulate receptor internalization or indirectly by reducing Glut1 mRNA levels (3). Additional studies indicate that TXNIP plays a role in the regulation of insulin mRNA transcription (4). Microarray analyses indicate that TXNIP acts downstream of PPARγ and is a putative tumor suppressor that may control thyroid cancer cell progression (5). In addition, the TXNIP protein may be a potential therapeutic target for the treatment of type 2 diabetes and some disorders related to ER-stress (6). |
| 存放说明 | -20C |
| 计算分子量 | 55 |
Western blot analysis of extracts from various cell lines using TXNIP (D5F3E) Rabbit mAb. | |
Immunoprecipitation of TXNIP from RL-7 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or TXNIP (D5F3E) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using TXNIP (D5F3E) Rabbit mAb. Mouse Anti-rabbit IgG (Light-Chain Specific) (L57A3) mAb #3677 was used as the secondary antibody. |
